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Universitätsklinikum Marburg
Justus-Liebig-Universität Giessen
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KFO309 - The clinical research unit Virus Induced Lung injury

All Publications

A novel non-invasive and echocardiography-derived method for quantification of right ventricular pressure-volume loops

Richter MJ, Yogeswaran A, Husain-Syed F, Vadász I, Rako Z, Mohajerani E, Ghofrani HA, Naeije R, Seeger W, Herberg U, Rieth A, Tedford RJ, Grimminger F, Gall H, Tello K

Eur Heart J Cardiovasc Imaging 2022 Mar 22;23(4):498-507. doi: 10.1093/ehjci/jeab038

No substantial preexisting B cell immunity against SARS-CoV-2 in healthy adults

Ercanoglu MS, Gieselmann L, Dähling S, Poopalasingam N, Detmer S, Koch M, Korenkov M, Halwe S, Klüver M, Di Cristanziano V, Janicki H, Schlotz M, Worczinski J, Gathof B, Gruell H, Zehner M, Becker S, Vanshylla K, Kreer C, Klein F

iScience 2022 Mar 18;25(3):103951. doi: 10.1016/j.isci.2022.103951

Effects of Receptor Specificity and Conformational Stability of Influenza A Virus Hemagglutinin on Infection and Activation of Different Cell Types in Human PBMCs

Dorna J, Kaufmann A, Bockmann V, Raifer H, West J, Matrosovich M, Bauer S

Front Immunol 2022 Mar 14;13:827760. doi: 10.3389/fimmu.2022.827760

Structural insight into Marburg virus nucleoprotein-RNA complex formation

Fujita-Fujiharu Y, Sugita Y, Takamatsu Y, Houri K, Igarashi M, Muramoto Y, Nakano M, Tsunoda Y, Taniguchi I, Becker S, Noda T

Nat Commun 2022 Mar 4;13(1):1191. doi: 10.1038/s41467-022-28802-x

Rocaglates as Antivirals: Comparing the Effects on Viral Resistance, Anti-Coronaviral Activity, RNA-Clamping on eIF4A and Immune Cell Toxicity

Obermann W, Friedrich A, Madhugiri R, Klemm P, Mengel JP, Hain T, Pleschka S, Wendel HG, Hartmann RK, Schiffmann S, Ziebuhr J, Müller C, Grünweller A

Viruses 2022 Mar 3;14(3):519. doi: 10.3390/v14030519

SIAH ubiquitin E3 ligases as modulators of inflammatory gene expression

Schmitz ML, Dreute J, Pfisterer M, Günther S, Kracht M, Chillappagari S

Heliyon 2022 Mar 1;8(3):e09029. doi: 10.1016/j.heliyon.2022.e09029

ADAM8 signaling drives neutrophil migration and ARDS severity

Conrad C, Yildiz D, Cleary SJ, Margraf A, Cook L, Schlomann U, Panaretou B, Bowser JL, Karmouty-Quintana H, Li J, Berg NK, Martin SC, Aljohmani A, Moussavi-Harmami SF, Wang, KM, Tian JJ, Magnen M, Calet C, Qiu L, Sinder JP, Eltzschig HK, CAPSys Study Group, Bertrams W, Herold S, Suttorp N, Schmeck B, Ball ZT, Zarbock A, Looney MR, Bartsch JW

JCI Insight 2022 Feb 8; 7(3): e149870, doi: 10.1172/jci.insight.149870

Proteomic landscape of SARS-CoV-2- and MERS-CoV-infected primary human renal epithelial cells

Kohli A, Sauerhering L, Fehling SK, Klann K, Geiger H, Becker S, Koch B, Baer PC, Strecker T, Münch C

Life Sci Alliance 2022 Feb 2;5(5):e202201371. doi: 10.26508/lsa.202201371

Update on the Features and Measurements of Experimental Acute Lung Injury in Animals: An Official American Thoracic Society Workshop Report

Kulkarni HS, Lee JS, Bastarache JA, Kuebler WM, Downey GP, Albaiceta GM, Altemeier WA, Artigas A, Bates JHT, Calfee CS, Dela Cruz CS, Dickson RP, Englert JA, Everitt JI, Fessler MB, Gelman AE, Gowdy KM, Groshong SD, Herold S, Homer RJ, Horowitz JC, Hsia CCW, Kurahashi K, Laubach VE, Looney MR, Lucas R, Mangalmurti NS, Manicone AM, Martin TR, Matalon S, Matthay MA, McAuley DF, McGrath-Morrow SA, Mizgerd JP, Montgomery SA, Moore BB, Noël A, Perlman CE, Reilly JP, Schmidt EP, Skerrett SJ, Suber TL, Summers C, Suratt BT, Takata M, Tuder R, Uhlig S, Witzenrath M, Zemans RL, Matute-Bello G

Am J Respir Cell Mol Biol 2022 Feb;66(2):e1-e14. doi: 10.1165/rcmb.2021-0531ST

An essential function for autocrine hedgehog signaling in epithelial proliferation and differentiation in the trachea

Yin W, Liontos A, Koepke J, Ghoul M, Mazzocchi L, Liu X, Lu C, Wu H, Fysikopoulos A, Sountoulidis A, Seeger W, Ruppert C, Günther A, Stainier DYR, Samakovlis C

Development 2022 Feb 1;149(3):dev199804. doi: 10.1242/dev.199804

Based Therapies to Prevent or Treat BPD-A Narrative Review on Advances and Ongoing Challenges

Goetz MJ, Kremer S, Behnke J, Staude B, Shahzad T, Holzfurtner L, Chao CM, Morty RE, Bellusci S, Ehrhardt H

Int J Mol Sci 2021 Jan 24;22(3):1138. doi: 10.3390/ijms22031138

RNA-Cholesterol Nanoparticles Function as Potent Immune Activators via TLR7 and TLR8

Obermann HL, Lederbogen II, Steele J, Dorna J, Sander LE, Engelhardt K, Bakowsky U, Kaufmann A, Bauer S

Front Immunol 2022 Jan 21;12:658895. doi: 10.3389/fimmu.2021.658895

Autoantibodies targeting cytokines and connective tissue disease autoantigens are common in acute non-SARS-CoV-2 infections

Feng A, Yang E, Moore A, Dhingra S, Chang S, Yin X, Pi R, Mack E, Völkel S, Geßner R, Gundisch M, Neubauer A, Renz H, Tsiodras S, Fragkou P, Asuni A, Levitt J, Wilson J, Leong M, Lumb J, Mao R, Pinedo K, Roque J, Richards C, Stabile M, Swaminathan G, Salagianni M, Triantafyllia V, Bertrams W, Blish C, Carette J, Frankovich J, Meffre E, Nadeau KC, Singh U, Wang T, Luning Prak E, Herold S, Andreakos E, Schmeck B, Skevaki C, Rogers A, Utz P

Res Sq 2022 Jan 20;rs.3.rs-1233038. doi: 10.21203/rs.3.rs-1233038/v1. Preprint

Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients

Aschenbrenner AC, Mouktaroudi M, Krämer B, Oestreich M, Antonakos N, Nuesch-Germano M, Gkizeli K, Bonaguro L, Reusch N, Baßler K, Saridaki M, Knoll R, Pecht T, Kapellos TS, Doulou S, Kröger C, Herbert M, Holsten L, Horne A, Gemünd ID, Rovina N, Agrawal S, Dahm K, van Uelft M, Drews A, Lenkeit L, Bruse N, Gerretsen J, Gierlich J, Becker M, Händler K, Kraut M, Theis H, Mengiste S, De Domenico E, Schulte-Schrepping J, Seep L, Raabe J, Hoffmeister C, ToVinh M, Keitel V, Rieke G, Talevi V, Skowasch D, Aziz NA, Pickkers P, van de Veerdonk FL, Netea MG, Schultze JL, Kox M, Breteler MMB, Nattermann J, Koutsoukou A, Giamarellos-Bourboulis EJ, Ulas T; German COVID-19 Omics Initiative (DeCOI)

Genome Med 2021 Jan 13;13(1):7. doi: 10.1186/s13073-020-00823-5

Longitudinal Multi-omics Analyses Identify Responses of Megakaryocytes, Erythroid Cells, and Plasmablasts as Hallmarks of Severe COVID-19

Bernardes JP, Mishra N, Tran F, Bahmer T, Best L, Blase JI, Bordoni D, Franzenburg J, Geisen U, Josephs-Spaulding J, Köhler P, Künstner A, Rosati E, Aschenbrenner AC, Bacher P, Baran N, Boysen T, Brandt B, Bruse N, Dörr J, Dräger A, Elke G, Ellinghaus D, Fischer J, Forster M, Franke A, Franzenburg S, Frey N, Friedrichs A, Fuß J, Glück A, Hamm J, Hinrichsen F, Hoeppner MP, Imm S, Junker R, Kaiser S, Kan YH, Knoll R, Lange C, Laue G, Lier C, Lindner M, Marinos G, Markewitz R, Nattermann J, Noth R, Pickkers P, Rabe KF, Renz A, Röcken C, Rupp J, Schaffarzyk A, Scheffold A, Schulte-Schrepping J, Schunk D, Skowasch D, Ulas T, Wandinger KP, Wittig M, Zimmermann J, Busch H, Hoyer BF, Kaleta C, Heyckendorf J, Kox M, Rybniker J, Schreiber S, Schultze JL, Rosenstiel P; HCA Lung Biological Network; Deutsche COVID-19 Omics Initiative (DeCOI)

Immunity 2020 Dec 15;53(6):1296-1314.e9. doi: 10.1016/j.immuni.2020.11.017