KFO309 - The clinical research unit Virus Induced Lung injury

All Publications

Effects of Receptor Specificity and Conformational Stability of Influenza A Virus Hemagglutinin on Infection and Activation of Different Cell Types in Human PBMCs

Dorna J, Kaufmann A, Bockmann V, Raifer H, West J, Matrosovich M, Bauer S

Front Immunol 2022 Mar 14;13:827760. doi: 10.3389/fimmu.2022.827760

ADAM8 signaling drives neutrophil migration and ARDS severity

Conrad C, Yildiz D, Cleary SJ, Margraf A, Cook L, Schlomann U, Panaretou B, Bowser JL, Karmouty-Quintana H, Li J, Berg NK, Martin SC, Aljohmani A, Moussavi-Harmami SF, Wang, KM, Tian JJ, Magnen M, Calet C, Qiu L, Sinder JP, Eltzschig HK, CAPSys Study Group, Bertrams W, Herold S, Suttorp N, Schmeck B, Ball ZT, Zarbock A, Looney MR, Bartsch JW

JCI Insight 2022 Feb 8; 7(3): e149870, doi: 10.1172/jci.insight.149870

Based Therapies to Prevent or Treat BPD-A Narrative Review on Advances and Ongoing Challenges

Goetz MJ, Kremer S, Behnke J, Staude B, Shahzad T, Holzfurtner L, Chao CM, Morty RE, Bellusci S, Ehrhardt H

Int J Mol Sci 2021 Jan 24;22(3):1138. doi: 10.3390/ijms22031138

Autoantibodies targeting cytokines and connective tissue disease autoantigens are common in acute non-SARS-CoV-2 infections

Feng A, Yang E, Moore A, Dhingra S, Chang S, Yin X, Pi R, Mack E, Völkel S, Geßner R, Gundisch M, Neubauer A, Renz H, Tsiodras S, Fragkou P, Asuni A, Levitt J, Wilson J, Leong M, Lumb J, Mao R, Pinedo K, Roque J, Richards C, Stabile M, Swaminathan G, Salagianni M, Triantafyllia V, Bertrams W, Blish C, Carette J, Frankovich J, Meffre E, Nadeau KC, Singh U, Wang T, Luning Prak E, Herold S, Andreakos E, Schmeck B, Skevaki C, Rogers A, Utz P

Res Sq 2022 Jan 20;rs.3.rs-1233038. doi: 10.21203/rs.3.rs-1233038/v1. Preprint

Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients

Aschenbrenner AC, Mouktaroudi M, Krämer B, Oestreich M, Antonakos N, Nuesch-Germano M, Gkizeli K, Bonaguro L, Reusch N, Baßler K, Saridaki M, Knoll R, Pecht T, Kapellos TS, Doulou S, Kröger C, Herbert M, Holsten L, Horne A, Gemünd ID, Rovina N, Agrawal S, Dahm K, van Uelft M, Drews A, Lenkeit L, Bruse N, Gerretsen J, Gierlich J, Becker M, Händler K, Kraut M, Theis H, Mengiste S, De Domenico E, Schulte-Schrepping J, Seep L, Raabe J, Hoffmeister C, ToVinh M, Keitel V, Rieke G, Talevi V, Skowasch D, Aziz NA, Pickkers P, van de Veerdonk FL, Netea MG, Schultze JL, Kox M, Breteler MMB, Nattermann J, Koutsoukou A, Giamarellos-Bourboulis EJ, Ulas T; German COVID-19 Omics Initiative (DeCOI)

Genome Med 2021 Jan 13;13(1):7. doi: 10.1186/s13073-020-00823-5

Longitudinal Multi-omics Analyses Identify Responses of Megakaryocytes, Erythroid Cells, and Plasmablasts as Hallmarks of Severe COVID-19

Bernardes JP, Mishra N, Tran F, Bahmer T, Best L, Blase JI, Bordoni D, Franzenburg J, Geisen U, Josephs-Spaulding J, Köhler P, Künstner A, Rosati E, Aschenbrenner AC, Bacher P, Baran N, Boysen T, Brandt B, Bruse N, Dörr J, Dräger A, Elke G, Ellinghaus D, Fischer J, Forster M, Franke A, Franzenburg S, Frey N, Friedrichs A, Fuß J, Glück A, Hamm J, Hinrichsen F, Hoeppner MP, Imm S, Junker R, Kaiser S, Kan YH, Knoll R, Lange C, Laue G, Lier C, Lindner M, Marinos G, Markewitz R, Nattermann J, Noth R, Pickkers P, Rabe KF, Renz A, Röcken C, Rupp J, Schaffarzyk A, Scheffold A, Schulte-Schrepping J, Schunk D, Skowasch D, Ulas T, Wandinger KP, Wittig M, Zimmermann J, Busch H, Hoyer BF, Kaleta C, Heyckendorf J, Kox M, Rybniker J, Schreiber S, Schultze JL, Rosenstiel P; HCA Lung Biological Network; Deutsche COVID-19 Omics Initiative (DeCOI)

Immunity 2020 Dec 15;53(6):1296-1314.e9. doi: 10.1016/j.immuni.2020.11.017

eIF2B-capturing viral protein NSs suppresses the integrated stress response

Kashiwagi K, Shichino Y, Osaki T, Sakamoto A, Nishimoto M, Takahashi M, Mito M, Weber F, Ikeuchi Y, Iwasaki S, Ito T

Nat Commun Dec 7;12(1):7102. doi: 10.1038/s41467-021-27337-x

Unmasking right ventricular-arterial uncoupling during fluid challenge in pulmonary hypertension

Kremer N, Rako Z, Douschan P, Gall H, Ghofrani HA, Grimminger F, Guth S, Naeije R, Rieth A, Schulz R, Seeger W, Tedford RJ, Vadász I, Vanderpool R, Wiedenroth CB, Richter MJ, Tello K

J Heart Lung Transplant 2022 Mar;41(3):345-355. doi: 10.1016/j.healun.2021.11.019

SARS-CoV-2 infection triggers profibrotic macrophage responses and lung fibrosis

Wendisch D, Dietrich O, Mari T, von Stillfried S, Ibarra IL, Mittermaier M, Mache C, Chua RL; Knoll R, Timm S, Brumhard S, Krammer T, Zauber H, Hiller AL, Pascual-Reguant A, Mothes R, Bülow RD, Schulze J, Leipold AM, Djudjaj S, Erhard F, Geffers R, Pott F, Kazmierski J, Radke J, Pergantis P, Baßler K, Conrad C, Aschenbrenner AC, Sawitzki B, Landthaler M, Wyler E, Horst D, Deutsche COVID-19 OMICS Initiative (DECOI), Hippenstiel S, Hocke A, Heppner FL, Uhrig A, Garcia C, Machleidt F, Herold S, Elezkurtaj S, Thibeault C, Witzenrath M, Cochain C, Suttorp N, Drosten C, Goffinet C, Kurth F, Schultze JL, Radbruch H, Ochs M, Eils R, Müller-Redetzky H, Hauser AE, Luecken MD, Theis FJ, Conrad C, Wolff T, Boor P, Selbach M, Saliba A-E, Sander LE

Cell 2021 Dec 22; 184(26): 6243–6261.e27, doi: 10.1016/j.cell.2021.11.033

Mechanisms of Hypercapnia-Induced Endoplasmic Reticulum Dysfunction

Kryvenko V, Vadász I

Front Physiol 2021 Nov 19;12:735580. doi: 10.3389/fphys.2021.735580. PMID: 34867444; PMCID: PMC8640499.

Renal markers for monitoring acute kidney injury transition to chronic kidney disease after COVID-19

Husain-Syed F, Villa G, Wilhelm J, Samoni S, Matt U, Vadász I, Tello K, Jennert B, Dietrich H, Trauth J, Kassoumeh S, Arneth B, Renz H, Sander M, Herold S, Seeger W, Schunk SJ, Speer T, Birk HW, Ronco C

Nephrol Dial Transplant 2021 Nov 9;36(11):2143-2147. doi: 10.1093/ndt/gfab235

Novel transfection methods in primary lung cell cultures

Kryvenko V, Vadász I

Am J Physiol Lung Cell Mol Physiol 2021 Oct 1;321(4):L734-L735. doi: 10.1152/ajplung.00371.2021. Epub 2021 Sep 22. PMID: 34549594

Multi-level inhibition of coronavirus replication by chemical ER stress

Samer-Shaban M, Müller C, Mayr-Buro C, Weiser H, Meier-Soelch J, Albert BV, Weber A, Linne U, Hain T, Babayev I, Karl N, Hofmann N, Becker S, Herold S, Schmitz ML, Ziebuhr J, Kracht M

Nat Commun 2021; 12: 5536, doi: 10.1038/s41467-021-25551-1

TRAF2 Is a Novel Ubiquitin E3 Ligase for the Na,K-ATPase β-Subunit That Drives Alveolar Epithelial Dysfunction in Hypercapnia

Gabrielli NM, Mazzocchi LC, Kryvenko V, Tello K, Herold S, Morty RE, Grimminger F, Dada LA, Seeger W, Sznaijder JL, Vadász I

Front Cell Dev Biol 2021 Jul 2;9:689983. doi: 10.3389/fcell.2021.689983

Hypercapnia Induces Inositol-Requiring Enzyme 1α–Driven Endoplasmic Reticulum–associated Degradation of the Na,K-ATPase β-Subunit

Kryvenko V, Wessendorf M, Tello K, Herold S, Morty RE, Seeger W, Vadász I

Am J Respir Cell Mol Biol 2021 Dec;65(6):615-629. doi: 10.1165/rcmb.2021-0114OC