KFO309 - The clinical research unit Virus Induced Lung injury

Principal Investigators

Werner Seeger

Prof. Dr. med. Werner Seeger


Justus Liebig University
Department of Internal Medicine II
Klinikstr. 33; 35392 Giessen

Susanne Herold

Prof. Dr. med. Susanne Herold , PhD


Justus Liebig University
Department of Internal Medicine II
Klinikstr. 33; 35392 Giessen


Inhaled GM-CSF in CAP-associated ARDS: Analyses of GM-CSF-induced regenerative signatures in the alveolar compartment from patients with viral pneumonia included in the GI-HOPE study


GM-CSF (granulocyte/macrophage colony-stimulating factor) was found to be highly protective in pre-clinical models of pneumonia-associated lung injury including viral infection. GM-CSF is a key activator of alveolar macrophage and dendritic cell function in the infected alveolar compartment, as it significantly improves gram-positive and gram-negative bacterial clearance and antiviral functions in mice. Moreover, there is first evidence of a beneficial effect of inhaled GM-CSF in patients with severe pneumonia/ARDS. Of note, the presence of a “healthy” microbiome was recently found to be crucial for triggering endogenous alveolar GM-CSF release for activation of alveolar macrophage antimicrobial/antiviral functions. Our recent findings suggest that, beyond its important function in macrophage activation, endogenous as well as intratracheally administered GM-CSF directly impacts the bronchoalveolar epithelial stem cell (BASC) niche during infectious lung injury and drives coordinated regeneration of the alveolar epithelium resulting in restoration of barrier function. However, the molecular mechanisms and the stem cell niche components involved in this GM-CSF effect are not well defined. 
A placebo-controlled, randomized clinical phase II investigator-initiated trial (GI-HOPE, NCT02595060) currently addresses the adjunctive therapeutic role of aerosolized GM-CSF in patients with pneumonia-related ARDS. In addition to the unique opportunity to evaluate aerosolized GM-CSF treatment effects in the patient sub-cohort with viral pneumonia-induced ARDS, sequential bronchoalveolar lavage fluid (BALF) and flow-sorted BAL cell subsets will be available to profile GM-CSF-induced changes at different levels of experimental complexity. To this end, the sequentially obtained biomaterials from pneumonia patients entering the GI-HOPE study will be combined with available gain- and loss of function transgenic mouse models and murine/human lung organoid models to answer the following questions: (i) What is the impact of GM-CSF application on BALF macrophages regarding subset composition and polarization phenotypes, state of differentiation of bone marrow-derived macrophages into tissue-resident cells to re-establish/regenerate the alveolar macrophage niche, and their transcriptome signatures assessed at single cell resolution in viral pneumonia patients included in the GI-HOPE trial? (ii) What are the molecular mechanisms of epithelial-regenerative effects induced by GM-CSF, and the underlying GM-CSF-dependent cellular cross-talk events between different cellular compartments of the bronchoalveolar stem cell niche? (iii) Is severe viral pneumonia in patients associated with reduced microbiota diversity or shifts in microbiome composition, and does this correlate with reduced endogenous pulmonary GM-CSF expression? Ultimately, these findings are envisioned to result in refined and improved GM-CSF treatment approaches.


Liver stiffness is associated with right heart dysfunction, cardiohepatic syndrome, and prognosis in pulmonary hypertension

J Heart Lung Transplant 2024 Jul;43(7):1105-1115. doi: 10.1016/j.healun.2024.02.013

Microscopic computed tomography with AI-CNN-powered image analysis: the path to phenotype bleomycin-induced lung injury

Am J Physiol Cell Physiol 2024 Jun 1;326(6):C1637-C1647. doi: 10.1152/ajpcell.00708.2023

The diverging roles of insulin-like growth factor binding proteins in pulmonary arterial hypertension

Vascul Pharmacol 2024 May 16;155:107379. doi: 10.1016/j.vph.2024.107379

miR-147b mediated suppression of DUSP8 promotes lung cancer progression

Oncogene 2024 Apr;43(16):1178-1189. doi: 10.1038/s41388-024-02969-7

Clinical and functional relevance of right ventricular contraction patterns in pulmonary hypertension

J Heart Lung Transplant 2023 Nov;42(11):1518-1528. doi: 10.1016/j.healun.2023.07.004

Echocardiographic evaluation of right ventricular diastolic function in pulmonary hypertension

ERJ Open Res 2023 Sep 18;9(5):00226-2023. doi: 10.1183/23120541.00226-2023

Influenza virus decreases albumin uptake and megalin expression in alveolar epithelial cells

Front Immunol 2023 Sep 1;14:1260973. doi: 10.3389/fimmu.2023.1260973

Case Report: Durable therapy response to Osimertinib in rare EGFR Exon 18 mutated NSCLC

Front Oncol 2023 Aug 16;13:1182391. doi: 10.3389/fonc.2023.1182391

Changes in Doppler-Derived Kidney Venous Flow and Adverse Cardiorenal Outcomes in Patients With Heart Failure

J Am Heart Assoc 2023 Aug 15;12(16):e030145. doi: 10.1161/JAHA.123.030145

The Role of the Redox Enzyme p66Shc in Biological Aging of the Lung

Aging Dis 2023 Jul 27. doi: 10.14336/AD.2023.0715

Hepatorenal dysfunction in patients with chronic thromboembolic pulmonary hypertension

Front Med (Lausanne) 2023 Jul 20;10:1207474. doi: 10.3389/fmed.2023.1207474

The HDAC2-SP1 Axis Orchestrates Protumor Macrophage Polarization

Cancer Res 2023 Jul 14;83(14):2345-2357. doi: 10.1158/0008-5472.CAN-22-1270

CEACAM6 as a Novel Therapeutic Target to Boost HO-1-mediated Antioxidant Defense in COPD

Am J Respir Crit Care Med 2023 Jun 15;207(12):1576-1590. doi: 10.1164/rccm.202208-1603OC

Nicotine promotes e-cigarette vapour-induced lung inflammation and structural alterations

Eur Respir J 2023 Apr 27:2200951. doi: 10.1183/13993003.00951-2022

Targeting Wnt-ß-Catenin-FOSL Signaling Ameliorates Right Ventricular Remodeling

Circ Res 2023 Apr 12. doi: 10.1161/CIRCRESAHA.122.321725

Imaging the right atrium in pulmonary hypertension: A systematic review and meta-analysis

J Heart Lung Transplant 2023 Apr;42(4):433-446. doi: 10.1016/j.healun.2022.11.007

Autoantibodies are highly prevalent in non-SARS-CoV-2 respiratory infections and critical illness

JCI Insight 2023 Feb 8;8(3):e163150. doi: 10.1172/jci.insight.163150

Notch1 Induces Defective Epithelial Surfactant Processing and Pulmonary Fibrosis

Am J Respir Crit Care Med 2023 Feb 1;207(3):283-299. doi: 10.1164/rccm.202105-1284OC

GDF-15 and soluble ST2 as biomarkers of right ventricular dysfunction in pulmonary hypertension

Biomark Med 2022 Dec;16(17):1193-1207. doi: 10.2217/bmm-2022-0395

Erratum: Antihistone Properties of C1 Esterase Inhibitor Protect against Lung Injury

Am J Respir Crit Care Med 2022 Nov 1;206(9):1184. doi: 10.1164/rccm.v206erratum6

Retraction: Nitric Oxide Synthase 2 Induction Promotes Right Ventricular Fibrosis

Am J Respir Cell Mol Biol 2022 Sep;67(3):414. doi: 10.1165/rcmb.v67retraction1

Targeting peptidyl-prolyl isomerase 1 in experimental pulmonary arterial hypertension

Eur Respir J 2022 Aug 25;60(2):2101698. doi: 10.1183/13993003.01698-2021.

Long-COVID – eine neue Herausforderung [Long COVID-a new challenge]

Inn Med (Heidelb) 2022 Aug;63(8):811-812. German. doi: 10.1007/s00108-022-01376-y

Hodgkin Lymphoma after Disseminated Mycobacterium genavense Infection, Germany

Emerg Infect Dis 2022 Jul;28(7):1506-1509. doi: 10.3201/eid2807.220425

Inhaled Iloprost Improves Right Ventricular Load-Independent Contractility in Pulmonary Hypertension

Am J Respir Crit Care Med 2022 Jul 1;206(1):111-114. doi: 10.1164/rccm.202201-0095LE

Utility and Drawbacks of Chimeric Antigen Receptor T Cell (CAR-T) Therapy in Lung Cancer

Front Immunol 2022 Jun 2;13:903562. doi: 10.3389/fimmu.2022.903562

A novel non-invasive and echocardiography-derived method for quantification of right ventricular pressure-volume loops

Eur Heart J Cardiovasc Imaging 2022 Mar 22;23(4):498-507. doi: 10.1093/ehjci/jeab038

SPARC, a Novel Regulator of Vascular Cell Function in Pulmonary Hypertension

Circulation 2022 Mar 22;145(12):916-933. doi: 10.1161/CIRCULATIONAHA.121.057001

Noncanonical HIPPO/MST Signaling via BUB3 and FOXO Drives Pulmonary Vascular Cell Growth and Survival

Circ Res 2022 Mar 4;130(5):760-778. doi: 10.1161/CIRCRESAHA.121.319100.

Risk assessment in pulmonary hypertension based on routinely measured laboratory parameters

J Heart Lung Transplant 2022 Mar;41(3):400-410. doi: 10.1016/j.healun.2021.10.018

Unmasking right ventricular-arterial uncoupling during fluid challenge in pulmonary hypertension

Cell Stem Cell 2018 Dec 6;23(6):794-805.e4. doi: 10.1016/j.stem.2018.10.011

Relevance of Cor Pulmonale in COPD With and Without Pulmonary Hypertension: A Retrospective Cohort Study

Front Cardiovasc Med 2022 Feb 16;9:826369. doi: 10.3389/fcvm.2022.826369

Picturing of the Lung Tumor Cellular Composition by Multispectral Flow Cytometry

Front Immunol 2022 Jan 25;13:827719. doi: 10.3389/fimmu.2022.827719

Author Correction: Deficiency of Axl aggravates pulmonary arterial hypertension via BMPR2

Commun Biol 2022 Jan 20;5(1):97. doi: 10.1038/s42003-022-03045-0

Genetic deletion of p66shc and/or cyclophilin D results in decreased pulmonary vascular tone

Cardiovasc Res 2022 Jan 7;118(1):305-315. doi: 10.1093/cvr/cvaa310

Epigenetic Mechanisms in Parenchymal Lung Diseases: Bystanders or Therapeutic Targets?

Int J Mol Sci 2022 Jan 4;23(1):546. doi: 10.3390/ijms23010546

Clinical Relevance of Right Atrial Functional Response to Treatment in Pulmonary Arterial Hypertension

Front Cardiovasc Med 2021 Dec 7;8:775039. doi: 10.3389/fcvm.2021.775039

Sex-specific differences in plasma levels of FXII, HK, and FXIIa-C1-esterase inhibitor complexes in community-acquired pneumonia

Am J Physiol Lung Cell Mol Physiol 2021 Oct 1;321(4):L764-L774. doi: 10.1152/ajplung.00162.2021

Impairment of hypoxic pulmonary vasoconstriction in acute respiratory distress syndrome

Eur Respir Rev 2021 Sep 15;30(161):210059. doi: 10.1183/16000617.0059-2021

Deficiency of Axl aggravates pulmonary arterial hypertension via BMPR2

Commun Biol 2021 Aug 24;4(1):1002. doi: 10.1038/s42003-021-02531-1

Hidden Treasures: Macrophage Long Non-Coding RNAs in Lung Cancer Progression

Cancers (Basel) 2021 Aug 17;13(16):4127. doi: 10.3390/cancers13164127

Exposomes to Exosomes: Exosomes as Tools to Study Epigenetic Adaptive Mechanisms in High-Altitude Humans

Int J Environ Res Public Health 2021 Aug 5;18(16):8280. doi: 10.3390/ijerph18168280

PINK1-mediated Mitophagy Contributes to Pulmonary Vascular Remodeling in Pulmonary Hypertension

Am J Respir Cell Mol Biol 2021 Aug;65(2):226-228. doi: 10.1165/rcmb.2021-0082LE

Understanding the Host in the Management of Pneumonia. An Official American Thoracic Society Workshop Report

Ann Am Thorac Soc 2021 Jul;18(7):1087-1097. doi: 10.1513/AnnalsATS.202102-209ST

Noninvasive Surrogate Markers of Pulmonary Hypertension Are Associated with Poor Survival in Patients with Lung Cancer

Am J Respir Crit Care Med 2021 May 15;203(10):1316-1319. doi: 10.1164/rccm.202005-2023LE

Right ventricular pressure-volume loop shape and systolic pressure change in pulmonary hypertension

Am J Physiol Lung Cell Mol Physiol 2021 May 1;320(5):L715-L725. doi: 10.1152/ajplung.00583.2020

The effect of long-term doxycycline treatment in a mouse model of cigarette smoke-induced emphysema and pulmonary hypertension

Am J Physiol Lung Cell Mol Physiol 2021 May 1;320(5):L903-L915. doi: 10.1152/ajplung.00048.2021

COVID-19: spot urine rather than bronchoalveolar lavage fluid analysis?

Crit Care 2021 Apr 30;25(1):162. doi: 10.1186/s13054-021-03579-5

Utilising biomarkers to predict right heart maladaptive phenotype: a step toward precision medicine

Eur Respir J 2021 Apr 8;57(4):2004506. doi: 10.1183/13993003.04506-2020

CILP1 as a biomarker for right ventricular maladaptation in pulmonary hypertension

Eur Respir J 2021 Apr 1;57(4):1901192. doi: 10.1183/13993003.01192-2019

Immunoglobulin deficiency as an indicator of disease severity in patients with COVID-19

Am J Physiol Lung Cell Mol Physiol 2021 Apr 1;320(4):L590-L599. doi: 10.1152/ajplung.00359.2020

WASP: a versatile, web-accessible single cell RNA-Seq processing platform

BMC Genomics 2021 Mar 18;22(1):195. doi: 10.1186/s12864-021-07469-6

Therapeutic Potential of Regorafenib-A Multikinase Inhibitor in Pulmonary Hypertension

Int J Mol Sci 2021 Feb 2;22(3):1502. doi: 10.3390/ijms22031502

Genetic Delivery and Gene Therapy in Pulmonary Hypertension

Int J Mol Sci 2021 Jan 25;22(3):1179. doi: 10.3390/ijms22031179

The Lung Vasculature: A Driver or Passenger in Lung Branching Morphogenesis?

Front Cell Dev Biol 2021 Jan 14;8:623868. doi: 10.3389/fcell.2020.623868

Interferon Regulatory Factor 9 Promotes Lung Cancer Progression via Regulation of Versican

Cancers (Basel) 2021 Jan 8;13(2):208. doi: 10.3390/cancers13020208

Targeting Jak-Stat Signaling in Experimental Pulmonary Hypertension

Am J Respir Cell Mol Biol 2021 Jan;64(1):100-114. doi: 10.1165/rcmb.2019-0431OC

Bayesian Inference Associates Rare KDR Variants with Specific Phenotypes in Pulmonary Arterial Hypertension

Circ Genom Precis Med 2020 Dec 15;14(1):e003155. doi: 10.1161/CIRCGEN.120.003155

SCRINSHOT enables spatial mapping of cell states in tissue sections with single-cell resolution

PLoS Biol 2020 Nov 20;18(11):e3000675. doi: 10.1371/journal.pbio.3000675

Novel composite clinical endpoints and risk scores used in clinical trials in pulmonary arterial hypertension

Pulm Circ 2020 Nov 18;10(4):2045894020962960. doi: 10.1177/2045894020962960

Long Noncoding RNA TYKRIL Plays a Role in Pulmonary Hypertension via the p53-mediated Regulation of PDGFRβ

Am J Respir Crit Care Med 2020 Nov 15;202(10):1445-1457. doi: 10.1164/rccm.201910-2041OC

Hypoxia-inducible factor signaling in pulmonary hypertension

J Clin Invest 2020 Nov 2;130(11):5638-5651. doi: 10.1172/JCI137558

Impact of litter size on survival, growth and lung alveolarization of newborn mouse pups

Ann Anat 2020 Nov;232:151579. doi: 10.1016/j.aanat.2020.151579

IRAG1 Deficient Mice Develop PKG1β Dependent Pulmonary Hypertension

Cells 2020 Oct 13;9(10):2280. doi: 10.3390/cells9102280

Advanced risk stratification of intermediate risk group in pulmonary arterial hypertension

Pulm Circ 2020 Oct 7;10(4):2045894020961739. doi: 10.1177/2045894020961739

Sex Differences in Right Ventricular-Pulmonary Arterial Coupling in Pulmonary Arterial Hypertension

Am J Respir Crit Care Med 2020 Oct 1;202(7):1042-1046. doi: 10.1164/rccm.202003-0807LE

Risk assessment in severe pulmonary hypertension due to interstitial lung disease

J Heart Lung Transplant 2020 Oct;39(10):1118-1125. doi: 10.1016/j.healun.2020.06.014

Metastasis-Associated Protein 2 Represses NF-κB to Reduce Lung Tumor Growth and Inflammation

Cancer Res 2020 Oct 1;80(19):4199-4211. doi: 10.1158/0008-5472.CAN-20-1158

Metabolism in tumour-associated macrophages: a quid pro quo with the tumour microenvironment

Eur Respir Rev 2020 Oct 1;29(157):200134. doi: 10.1183/16000617.0134-2020

Evaluation of pulmonary hypertension by right heart catheterisation: does timing matter?

Eur Respir J 2020 Sep 3;56(3):1901892. doi: 10.1183/13993003.01892-2019

Pre-transplant renal functional reserve and renal function after lung transplantation

J Heart Lung Transplant 2020 Sep;39(9):970-974. doi: 10.1016/j.healun.2020.05.011

Decreased Thymic Output Contributes to Immune Defects in Septic Patients

J Clin Med 2020 Aug 20;9(9):2695. doi: 10.3390/jcm9092695

Besnoitia besnoiti-driven endothelial host cell cycle alteration

Parasitol Res 2020 Aug;119(8):2563-2577. doi: 10.1007/s00436-020-06744-x

Impact of SARS-CoV-2 pandemic on pulmonary hypertension out-patient clinics in Germany: a multi-centre study

Pulm Circ 2020 Jul 23;10(3):2045894020941682. doi: 10.1177/2045894020941682

Fibroblast Growth Factor-14 Acts as Tumor Suppressor in Lung Adenocarcinomas

Cells 2020 Jul 22;9(8):1755. doi: 10.3390/cells9081755

Microenvironmental Th9 and Th17 lymphocytes induce metastatic spreading in lung cancer

J Clin Invest 2020 Jul 1;130(7):3560-3575. doi: 10.1172/JCI124037

Whole-genome sequencing of a sporadic primary immunodeficiency cohort

Nature 2020 Jul;583(7814):90-95. doi: 10.1038/s41586-020-2265-1

Whole-genome sequencing of patients with rare diseases in a national health system

Nature 2020 Jul;583(7814):96-102. doi: 10.1038/s41586-020-2434-2

Effect of p53 activation on experimental right ventricular hypertrophy

PLoS One 2020 Jun 19;15(6):e0234872. doi: 10.1371/journal.pone.0234872

Update on the "Choosing Wisely" initiative in infectious diseases in Germany

Infection 2020 Jun;48(3):317-321. doi: 10.1007/s15010-020-01400-z

NADPH oxidase subunit NOXO1 is a target for emphysema treatment in COPD

Nat Metab 2020 Jun;2(6):532-546. doi: 10.1038/s42255-020-0215-8

SPARCL1 as a biomarker of maladaptive right ventricular remodelling in pulmonary hypertension

Biomarkers 2020 May;25(3):290-295. doi: 10.1080/1354750X.2020.1745889

Cancer and pulmonary hypertension: Learning lessons and real-life interplay

Glob Cardiol Sci Pract 2020 Apr 30;2020(1):e202010. doi: 10.21542/gcsp.2020.10

Association of right atrial conduit phase with right ventricular lusitropic function in pulmonary hypertension

Int J Cardiovasc Imaging 2020 Apr;36(4):633-642. doi: 10.1007/s10554-019-01763-x

Characterization of GDF2 Mutations and Levels of BMP9 and BMP10 in Pulmonary Arterial Hypertension

Am J Respir Crit Care Med 2020 Mar 1;201(5):575-585. doi: 10.1164/rccm.201906-1141OC

Altered proteasome function in right ventricular hypertrophy

Cardiovasc Res 2020 Feb 1;116(2):406-415. doi: 10.1093/cvr/cvz103

The Multi-Modal Effect of the Anti-fibrotic Drug Pirfenidone on NSCLC

Front Oncol 2020 Jan 21;9:1550. doi: 10.3389/fonc.2019.01550

Evaluation and Prognostic Relevance of Right Ventricular-Arterial Coupling in Pulmonary Hypertension

Am J Respir Crit Care Med 2020 Jan 1;201(1):116-119. doi: 10.1164/rccm.201906-1195LE

Epithelial cell plasticity defines heterogeneity in lung cancer

Cell Signal 2020 Jan;65:109463. doi: 10.1016/j.cellsig.2019.109463

Is PKM2 Phosphorylation a Prerequisite for Oligomer Disassembly in Pulmonary Arterial Hypertension?

Am J Respir Crit Care Med 2019 Dec 15;200(12):1550-1554. doi: 10.1164/rccm.201904-0782LE

Doppler-Derived Renal Venous Stasis Index in the Prognosis of Right Heart Failure

J Am Heart Assoc 2019 Nov 5;8(21):e013584. doi: 10.1161/JAHA.119.013584

CAT score single item analysis in patients with COPD: Results from COSYCONET

Respir Med 2019 Nov;159:105810. doi: 10.1016/j.rmed.2019.105810

IRE1 Signaling As a Putative Therapeutic Target in Influenza Virus-induced Pneumonia

Am J Respir Cell Mol Biol 2019 Oct;61(4):537-540. doi: 10.1165/rcmb.2019-0123LE

Indefinite cytomegalovirus prophylaxis with valganciclovir after lung transplantation

Transpl Infect Dis 2019 Oct;21(5):e13138. doi: 10.1111/tid.13138

Update in Lung Infections and Tuberculosis 2018

Am J Respir Crit Care Med 2019 Aug 15;200(4):414-422. doi: 10.1164/rccm.201903-0606UP

Severe Emphysema in the SU5416/Hypoxia Rat Model of Pulmonary Hypertension

Am J Respir Crit Care Med 2019 Aug 15;200(4):515-518. doi: 10.1164/rccm.201902-0390LE

Clinical characteristics of patients with familial idiopathic pulmonary fibrosis (f-IPF)

BMC Pulm Med 2019 Jul 18;19(1):130. doi: 10.1186/s12890-019-0895-6

Regulation and role of the ER stress transcription factor CHOP in alveolar epithelial type-II cells

J Mol Med (Berl) 2019 Jul;97(7):973-990. doi: 10.1007/s00109-019-01787-9

Riociguat for treatment of pulmonary hypertension in COPD: a translational study

Eur Respir J 2019 Jun 27;53(6):1802445. doi: 10.1183/13993003.02445-2018

Bronchioalveolar stem cells are a main source for regeneration of distal lung epithelia in vivo

EMBO J 2019 Jun 17;38(12):e102099. doi: 10.15252/embj.2019102099

Evidence for the Fucoidan/P-Selectin Axis as a Therapeutic Target in Hypoxia-induced Pulmonary Hypertension

Am J Respir Crit Care Med 2019 Jun 1;199(11):1407-1420. doi: 10.1164/rccm.201806-1170OC

Multibeat Right Ventricular-Arterial Coupling during a Positive Acute Vasoreactivity Test

Am J Respir Crit Care Med 2019 Jun 1;199(11):e41-e42. doi: 10.1164/rccm.201809-1787IM

Protection against pressure overload-induced right heart failure by uncoupling protein 2 silencing

Cardiovasc Res 2019 Jun 1;115(7):1217-1227. doi: 10.1093/cvr/cvz049

miR-574-5p as RNA decoy for CUGBP1 stimulates human lung tumor growth by mPGES-1 induction

FASEB J. 2019 Jun;33(6):6933-6947. doi: 10.1096/fj.201802547R

Germline selection shapes human mitochondrial DNA diversity

Science 2019 May 24;364(6442):eaau6520. doi: 10.1126/science.aau6520

Targeting cyclin-dependent kinases for the treatment of pulmonary arterial hypertension

Nat Commun 2019 May 17;10(1):2204. doi: 10.1038/s41467-019-10135-x

A RASSF1A-HIF1α loop drives Warburg effect in cancer and pulmonary hypertension

Nat Commun 2019 May 13;10(1):2130. doi: 10.1038/s41467-019-10044-z

Increased frequency of the restless legs syndrome in adults with cystic fibrosis

Respir Med 2019 May;151:8-10. doi: 10.1016/j.rmed.2019.03.009

Nitric Oxide Synthase 2 Induction Promotes Right Ventricular Fibrosis

Am J Respir Cell Mol Biol 2019 Mar;60(3):346-356. doi: 10.1165/rcmb.2018-0069OC

Pulmonary hypertension in chronic lung disease and hypoxia

Eur Respir J 2019 Jan 24;53(1):1801914. doi: 10.1183/13993003.01914-2018

Reserve of Right Ventricular-Arterial Coupling in the Setting of Chronic Overload

Circ Heart Fail 2019 Jan;12(1):e005512. doi: 10.1161/CIRCHEARTFAILURE.118.005512

Evaluating Systolic and Diastolic Cardiac Function in Rodents Using Microscopic Computed Tomography

Circ Cardiovasc Imaging 2018 Dec;11(12):e007653. doi: 10.1161/CIRCIMAGING.118.007653

Transcriptome profiling reveals the complexity of pirfenidone effects in idiopathic pulmonary fibrosis

Eur Respir J 2018 Nov 22;52(5):1800564. doi: 10.1183/13993003.00564-2018

More on Single-Beat Estimation of Right Ventriculoarterial Coupling in Pulmonary Arterial Hypertension

Am J Respir Crit Care Med 2018 Sep 15;198(6):816-818. doi: 10.1164/rccm.201802-0283LE

Nintedanib in Severe Pulmonary Arterial Hypertension

Am J Respir Crit Care Med 2018 Sep 15;198(6):808-810. doi: 10.1164/rccm.201801-0195LE

Relevance of the TAPSE/PASP ratio in pulmonary arterial hypertension

Int J Cardiol 2018 Sep 1;266:229-235. doi: 10.1016/j.ijcard.2018.01.053.

Resolvin E1 and its precursor 18R-HEPE restore mitochondrial function in inflammation

Biochim Biophys Acta Mol Cell Biol Lipids 2018 Sep;1863(9):1016-1028. doi: 10.1016/j.bbalip.2018.06.011

Understanding alveolarization to induce lung regeneration

Respir Res 2018 Aug 6;19(1):148. doi: 10.1186/s12931-018-0837-5

MiCEE is a ncRNA-protein complex that mediates epigenetic silencing and nucleolar organization

Nat Genet 2018 Jul;50(7):990-1001. doi: 10.1038/s41588-018-0139-3

Treatment Options for Carbapenem- Resistant Gram-Negative Infections

Dtsch Arztebl Int 2018 May 21;115(20-21):345-352. doi: 10.3238/arztebl.2018.0345

Classical IL-6 signaling: a promising therapeutic target for pulmonary arterial hypertension

J Clin Invest 2018 May 1;128(5):1720-1723. doi: 10.1172/JCI120415

Identification of rare sequence variation underlying heritable pulmonary arterial hypertension

Nat Commun 2018 Apr 12;9(1):1416. doi: 10.1038/s41467-018-03672-4

Preoperative Renal Functional Reserve Predicts Risk of Acute Kidney Injury After Cardiac Operation

Ann Thorac Surg 2018 Apr;105(4):1094-1101. doi: 10.1016/j.athoracsur.2017.12.034

ASK1 Inhibition Halts Disease Progression in Preclinical Models of Pulmonary Arterial Hypertension

Am J Respir Crit Care Med 2018 Feb 1;197(3):373-385. doi: 10.1164/rccm.201703-0502OC

Impact of the mitochondria-targeted antioxidant MitoQ on hypoxia-induced pulmonary hypertension

Eur Respir J 2018 Feb 1:1701024. doi: 10.1183/13993003.01024-2017

Use of very old donors for lung transplantation: a dual-centre retrospective analysis

Eur J Cardiothorac Surg 2017 Dec 1;52(6):1049-1054. doi: 10.1093/ejcts/ezx202

p38 MAPK Inhibition Improves Heart Function in Pressure-Loaded Right Ventricular Hypertrophy

Am J Respir Cell Mol Biol 2017 Nov;57(5):603-614. doi: 10.1165/rcmb.2016-0374OC

A Dermatologist's Ammunition in the War Against Smoking: A Photoaging App

J Med Internet Res 2017 Sep 21;19(9):e326. doi: 10.2196/jmir.8743

Mitochondrial Complex IV Subunit 4 Isoform 2 Is Essential for Acute Pulmonary Oxygen Sensing

Circ Res 2017 Aug 4;121(4):424-438. doi: 10.1161/CIRCRESAHA.116.310482

Mesenchymal Stem Cells in Fibrotic Disease

Cell Stem Cell 2017 Aug 3;21(2):166-177. doi: 10.1016/j.stem.2017.07.011

Antihistone Properties of C1 Esterase Inhibitor Protect against Lung Injury

Am J Respir Crit Care Med 2017 Jul 15;196(2):186-199. doi: 10.1164/rccm.201604-0712OC

Epigenetic silencing of downstream genes mediated by tandem orientation in lung cancer

Sci Rep 2017 Jun 20;7(1):3896. doi: 10.1038/s41598-017-04248-w

The "Choosing Wisely" initiative in infectious diseases

Infection 2017 Jun;45(3):263-268. doi: 10.1007/s15010-017-0997-0

Pulmonary endothelial cell DNA methylation signature in pulmonary arterial hypertension

Oncotarget 2017 May 19;8(32):52995-53016. doi: 10.18632/oncotarget.18031

Pirfenidone exerts antifibrotic effects through inhibition of GLI transcription factors

FASEB J 2017 May;31(5):1916-1928. doi: 10.1096/fj.201600892RR

Inspiratory capacity is not altered in operable chronic thromboembolic pulmonary hypertension

Pulm Circ 2017 Apr-Jun;7(2):543-546. doi: 10.1177/2045893217709763

Stereological monitoring of mouse lung alveolarization from the early post-natal period to adulthood

Am J Physiol Lung Cell Mol Physiol 2017 Jun 1;312(6):L882-L895. doi: 10.1152/ajplung.00492.2016

Procedural safety of a fully implantable intravenous prostanoid pump for pulmonary hypertension

Clin Res Cardiol 2017 Mar;106(3):174-182. doi: 10.1007/s00392-016-1037-2

Two-Way Conversion between Lipogenic and Myogenic Fibroblastic Phenotypes Marks the Progression and Resolution of Lung Fibrosis

Cell Stem Cell 2017 Feb 2;20(2):261-273.e3. doi: 10.1016/j.stem.2016.10.004. Epub 2016 Nov 17. Erratum in: Cell Stem Cell. 2017 Apr 6;20(4):571

Tamoxifen dosing for Cre-mediated recombination in experimental bronchopulmonary dysplasia

Transgenic Res 2017 Feb;26(1):165-170. doi: 10.1007/s11248-016-9987-8

Clinical and Operative Determinants of Acute Kidney Injury after Cardiac Surgery

Cardiorenal Med 2020;10(5):340-352. doi: 10.1159/000507777

Principal Investigators

Werner Seeger

Prof. Dr. med. Werner Seeger


Justus Liebig University
Department of Internal Medicine II
Klinikstr. 33; 35392 Giessen

Susanne Herold

Prof. Dr. med. Susanne Herold , PhD


Justus Liebig University
Department of Internal Medicine II
Klinikstr. 33; 35392 Giessen


Project group

  • Nicole Tewes

    Nicole Tewes

    Study Nurse

  • Janina Trauth

    Dr. Janina Trauth

    Clinical Study Investigator, MD