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Universitätsklinikum Marburg
Justus-Liebig-Universität Giessen
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KFO309 - The clinical research unit Virus Induced Lung injury

All Publications

WASH activation controls endosomal recycling and EGFR and Hippo signaling during tumor-suppressive cell competition

Liu D, Tsarouhas V, Samakovlis C

Nat Commun 2022 Oct 21;13(1):6243. doi: 10.1038/s41467-022-34067-1

Pirfenidone exacerbates Th2-driven vasculopathy in a mouse model of systemic sclerosis-associated interstitial lung disease

Birnhuber A, Jandl K, Biasin V, Fließer E, Valzano F, Marsh LM, Krolczik C, Olschewski A, Wilhelm J, Toller W, Heinemann A, Olschewski H, Wygrecka M, Kwapiszewska G

Eur Respir J 2022 Oct 20;60(4):2102347. doi: 10.1183/13993003.02347-2021

Design, synthesis, and characterization of novel fluorogenic substrates of the proprotein convertases furin, PC1/3, PC2, PC5/6, and PC7

Lam van TV, Ivanova T, Lindberg I, Böttcher-Friebertshäuser E, Steinmetzer T, Hardes K

Anal Biochem 2022 Oct 15;655:114836. doi: 10.1016/j.ab.2022.114836

Fibrocytes boost tumor-supportive phenotypic switches in the lung cancer niche via the endothelin system

Weigert A, Zheng X, Nenzel A, Turkowski K, Günther S, Strack E, Sirait-Fischer E, Elwakeel E, Kur IM, Nikam VS, Valasarajan C, Winter H, Wissgott A, Voswinkel R, Grimminger F, Brüne B, Seeger W, Pullamsetti SS, Savai R

Nat Commun 2022 Oct 14;13(1):6078. doi: 10.1038/s41467-022-33458-8

An introduction to the Marburg virus vaccine consortium, MARVAC

Cross RW, Longini IM, Becker S, Bok K, Boucher D, Carroll MW, Díaz JV, Dowling WE, Draghia-Akli R, Duworko JT, Dye JM, Egan MA, Fast P, Finan A, Finch C, Fleming TR, Fusco J, Geisbert TW, Griffiths A, Günther S, Hensley LE, Honko A, Hunegnaw R, Jakubik J, Ledgerwood J, Luhn K, Matassov D, Meshulam J, Nelson EV, Parks CL, Rustomjee R, Safronetz D, Schwartz LM, Smith D, Smock P, Sow Y, Spiropoulou CF, Sullivan NJ, Warfield KL, Wolfe D, Woolsey C, Zahn R, Henao-Restrepo AM, Muñoz-Fontela C, Marzi A

PLoS Pathog 2022 Oct 13;18(10):e1010805. doi: 10.1371/journal.ppat.1010805

Diastereomeric Resolution Yields Highly Potent Inhibitor of SARS-CoV-2 Main Protease

Cooper MS, Zhang L, Ibrahim M, Zhang K, Sun X, Röske J, Göhl M, Brönstrup M, Cowell JK, Sauerhering L, Becker S, Vangeel L, Jochmans D, Neyts J, Rox K, Marsh GP, Maple HJ, Hilgenfeld R

J Med Chem 2022 Oct 13;65(19):13328-13342. doi: 10.1021/acs.jmedchem.2c01131

Shielding the mRNA-translation factor eIF2B from inhibitory p-eIF2 as a viral strategy to evade protein kinase R-mediated innate immunity

Wuerth JD, Weber F

Curr Opin Immunol 2022 Oct;78:102251. doi: 10.1016/j.coi.2022.102251

A universal SARS-CoV DNA vaccine inducing highly cross-reactive neutralizing antibodies and T cells

Appelberg S, Ahlén G, Yan J, Nikouyan N, Weber S, Larsson O, Höglund U, Aleman S, Weber F, Perlhamre E, Apro J, Gidlund EK, Tuvesson O, Salati S, Cadossi M, Tegel H, Hober S, Frelin L, Mirazimi A, Sällberg M

EMBO Mol Med Oct 10;14(10):e15821. doi: 10.15252/emmm.202215821

Monitoring autochthonous lung tumors induced by somatic CRISPR gene editing in mice using a secreted luciferase

Merle N, Elmshäuser S, Strassheimer F, Wanzel M, König AM, Funk J, Neumann M, Kochhan K, Helmprobst F, Pagenstecher A, Nist A, Mernberger M, Schneider A, Braun T, Borggrefe T, Savai R, Timofeev O, Stiewe T

Mol Cancer 2022 Oct 3;21(1):191. doi: 10.1186/s12943-022-01661-2

Integrated genomic surveillance enables tracing of person-to-person SARS-CoV-2 transmission chains during community transmission and reveals extensive onward transmission of travel-imported infections, Germany, June to July 2021

Houwaart T, Belhaj S, Tawalbeh E, Nagels D, Fröhlich Y, Finzer P, Ciruela P, Sabrià A, Herrero M, Andrés C, Antón A, Benmoumene A, Asskali D, Haidar H, von Dahlen J, Nicolai J, Stiller M, Blum J, Lange C, Adelmann C, Schroer B, Osmers U, Grice C, Kirfel PP, Jomaa H, Strelow D, Hülse L, Pigulla M, Kreuzer P, Tyshaieva A, Weber J, Wienemann T, Kohns Vasconcelos M, Hoffmann K, Lübke N, Hauka S, Andree M, Scholz CJ, Jazmati N, Göbels K, Zotz R, Pfeffer K, Timm J, Ehlkes L, Walker A, Dilthey AT; German COVID-19 OMICS Initiative (DeCOI); German COVID-19 OMICs Initiative (DeCOI)

Euro Surveill 2022 Oct;27(43):2101089. doi: 10.2807/1560-7917.ES.2022.27.43.2101089

CXCL13 is expressed in a subpopulation of neuroendocrine cells in the murine trachea and lung

Mahmoud W, Perniss A, Poharkar K, Soultanova A, Pfeil U, Hoek A, Bhushan S, Hain T, Gärtner U, Kummer W

Cell Tissue Res 2022 Oct;390(1):35-49. doi: 10.1007/s00441-021-03552-2

Host immune responses and possible therapeutic targets for viral respiratory tract infections in susceptible populations: a narrative review

Fragkou PC, Moschopoulos CD, Reiter R, Berger T, Skevaki C; ESCMID Study Group for Respiratory Viruses (ESGREV)

Clin Microbiol Infect 2022 Oct;28(10):1328-1334. doi: 10.1016/j.cmi.2022.03.010

T2-high asthma phenotypes across lifespan

Maison N, Omony J, Illi S, Thiele D, Skevaki C, Dittrich AM, Bahmer T, Rabe KF, Weckmann M, Happle C, Schaub B, Meyer M, Foth S, Rietschel E, Renz H, Hansen G, Kopp MV, von Mutius E, Grychtol R; ALLIANCE Study Group; ALLIANCE Study Group; Fuchs O, Roesler B, Welchering N, Kohistani-Greif N, Kurz J, Landgraf-Rauf K, Laubhahn K, Liebl C, Ege M, Hose A, Zeitlmann E, Berbig M, Marzi C, Schauberger C, Zissler U, Schmidt-Weber C, Ricklefs I, Diekmann G, Liboschik L, Voigt G, Sultansei L, Nissen G, König IR, Kirsten AM, Pedersen F, Watz H, Waschki B, Herzmann C, Abdo M, Biller H, Gaede KI, Bovermann X, Steinmetz A, Husstedt BL, Nitsche C, Veith V, Szewczyk M, Brinkmann F, Malik A, Schwerk N, Dopfer C, Price M, Jirmo AC, Habener A, DeLuca DS, Gaedcke S, Liu B, Calveron MR, Weber S, Schildberg T, van Koningsbruggen-Rietschel S, Alcazar M

Eur Respir J 2022 Sep 29;60(3):2102288. doi: 10.1183/13993003.02288-2021

Selected commensals educate the intestinal vascular and immune system for immunocompetence

Romero R, Zarzycka A, Preussner M, Fischer F, Hain T, Herrmann JP, Roth K, Keber CU, Suryamohan K, Raifer H, Luu M, Leister H, Bertrams W, Klein M, Shams-Eldin H, Jacob R, Mollenkopf HJ, Rajalingam K, Visekruna A, Steinhoff U

Microbiome 2022 Sep 28;10(1):158. doi: 10.1186/s40168-022-01353-5

Myeloid CD169/Siglec1: An immunoregulatory biomarker in viral disease

Herzog S, Fragkou PC, Arneth BM, Mkhlof S, Skevaki C

Front Med (Lausanne) 2022 Sep 23;9:979373. doi: 10.3389/fmed.2022.979373