KFO309 - The clinical research unit Virus Induced Lung injury

All Publications

Ferreting out viral pathogenesis

Wuerth JD, Weber F.

Nat Microbiol. 2019 Mar;4(3):384-385. doi: 10.1038/s41564-019-0390-0.2019

ADAR1 Is Required for Dendritic Cell Subset Homeostasis and Alveolar Macrophage Function

Baal N, Cunningham, S, Obermann HL, Thomas J, Lippitsch A, Dietert K, Gruber AD, Kaufmann A, Michel G, Nist A, Stiewe T, Rupp O, Goesmann A, Zukunft S, Fleming I, Bein G, Lohmeyer J, Bauer S, Hackstein H

J Immunol 2019 202(4):1099-1111. doi: 10.4049/jimmunol.1800269

Histone variant H2A.Z deposition and acetylation directs the canonical Notch signaling response

Giaimo BD, Ferrante F, Vallejo DM, Hein K, Gutierrez-Perez I, Nist A, Stiewe T, Mittler G, Herold S, Zimmermann T, Bartkuhn M, Schwarz P, Oswald F, Dominguez M, Borggrefe T

Nucleic Acids Res 2018 doi: 10.1093/nar/gky551

Transmission of microRNA antimiRs to mouse offspring via the maternal-placental-fetal unit

Honig J, Mizikova I, Nardiello C, Surate Solaligue DE, Daume MJ, Vadasz I, Mayer K, Herold S, Gunther S, Seeger W, Morty RE

RNA 2018 24(6):865-879. doi: 10.1261/rna.063206.117

Targeting transglutaminase 2 partially restores extracellular matrix structure but not alveolar architecture in experimental bronchopulmonary dysplasia

Mizikova I, Pfeffer T, Nardiello C, Surate Solaligue DE, Steenbock H, Tatsukawa H, Silva DM, Vadasz I, Herold S, Pease RJ, Iismaa SE, Hitomi K, Seeger W, Brinckmann J, Morty RE

Febs J 2018 doi: 10.1111/febs.14596. [Epub ahead of print]

Resident alveolar macrophages are master regulators of arrested alveolarization in experimental bronchopulmonary dysplasia

Kalymbetova TV, Selvakumar B, Rodriguez-Castillo JA, Gunjak M, Malainou C, Heindl MR, Moiseenko A, Chao CM, Vadasz I, Mayer K, Lohmeyer J, Bellusci S, Bottcher-Friebertshauser E, Seeger W, Herold S, Morty RE

J Pathol 2018 245(2):153-159. doi: 10.1002/path.5076

Digital Image Analyses on Whole-Lung Slides in Mouse Models of Acute Pneumonia

Dietert K, Nouailles G, Gutbier B, Reppe K, Berger S, Jiang X, Schauer AE, Hocke AC, Herold S, Slevogt H, Witzenrath M, Suttorp N, Gruber AD

AJRCMB 2018 58(4):440-448 doi: 10.1165/rcmb.2017-0337MA10.1165/rcmb.2017-0337MA

Inhibition of cytosolic phospholipase A2alpha impairs an early step of coronavirus replication in cell culture

Müller C, Hardt M, Schwudke D, Neuman BW, Pleschka S, Ziebuhr J

J Virol 2018 92(4). pii: e01463-17 doi: 10.1128/JVI.01463-17

Spectrum of pathogen- and model-specific histopathologies in mouse models of acute pneumonia

Dietert K, Gutbier B, Wienhold SM, Reppe K, Jiang X, Yao L, Chaput C, Naujoks J, Brack M, Kupke A, Peteranderl C, Becker S, von Lachner C, Baal N, Slevogt H, Hocke AC, Witzenrath M, Opitz B, Herold S, Hackstein H, Sander LE, Suttorp N, Gruber AD

PLoS ONE 2017 12(11):e0188251

Restoration of Megalin-Mediated Clearance of Alveolar Protein as a Novel Therapeutic Approach for Acute Lung Injury

Vohwinkel CU, Buchäckert Y, Al-Tamari HM, Mazzocchi LC, Eltzschig HK, Mayer K, Morty RE, Herold S, Seeger W, Pullamsetti SS, Vadász I

ATSJournals 2017 57(5):589-602

TGF-β inhibits alveolar protein transport by promoting shedding, regulated intramembrane proteolysis, and transcriptional downregulation of megalin

Mazzocchi LCVohwinkel CUMayer K, Herold SMorty RESeeger WVadász I

AJPLung 2017 313 (5) L807-L824

A novel mouse Cre-driver line targeting Perilipin 2-expressing cells in the neonatal lung

Ntokou A, Szibor M, Rodriguez-Castillo JA, Quantius J, Herold S, El Agha E, Bellusci S, Salwig I, Braun T, Voswinckel R, Seeger W, Morty RE, Ahlbrecht K

Genesis 2017 55(12):e23080

Perturbations to lysyl oxidase expression broadly influence the transcriptome of lung fibroblasts

Mizikova I, Palumbo F, Tabi T, Herold S, Vadasz I, Mayer K, Seeger W, Morty RE

Physiol Genomics 2017 49(8):416-429. doi: 10.1152/physiolgenomics.00026.2017

Hypercapnia Impairs ENaC Cell Surface Stability by Promoting Phosphorylation, Polyubiquitination and Endocytosis of beta-ENaC in a Human Alveolar Epithelial Cell Line

Gwozdzinska P, Buchbinder BA, Mayer K, Herold S, Morty RE, Seeger W, Vadasz I

Front Immunol 2017 8:591 doi: 10.3389/fimmu.2017.00591

pH-optimum of hemagglutinin-mediated membrane fusion determines sensitivity of influenza A viruses to the interferon-induced antiviral state and IFITMs.

Gerlach T, Hensen L, Matrosovich T, Bergmann J, Winkler M, Peteranderl C, Klenk HD, Weber F, Herold S, Pöhlmann S, Matrosovich M.

J Virol. 2017 91(11) e00246-17 doi: 10.1128/JVI.00246-17