KFO309 - The clinical research unit Virus Induced Lung injury

Principal Investigators

Torsten Hain

PD Dr. rer. nat. Torsten Hain

Justus Liebig University Giessen
Institute of Medical Microbiology 
Schubertstraße 81; 35392 Giessen

+49-641-99-39860
Alexander Goesmann

Prof. Dr. Alexander Goesmann

Systems Biology
Heinrich-Buff-Ring 58; 35392 Giessen

+49 641 99-35800
Jochen Wilhelm

Dr. rer. nat. Jochen Wilhelm

Justus Liebig University Giessen
Department of Medicine II
Gaffkystr. 11; 35392 Giessen

+49-641-99-42545
Jürgen Lohmeyer

Prof. Dr. med. Jürgen Lohmeyer

Vice speaker

Justus Liebig University Giessen
Department of Internal Medicine II
Klinikstr. 33; 35392 Giessen

+49-641-985-57060

Core unit “Genome signatures and integrated systems biology of pathogen-host interaction and cellular networks in the infected and injured lung”

Summary

Understanding cell-specific gene regulatory events and their impact on cellular networks in infected lungs requires an integrative platform which delivers primary lung cells/tissue including highly purified cell populations even of rare subsets, high-throughput genomic and cutting edge epigenetic analyses as well as advanced data processing for bioinformatic exploitation. As such, Z1 provides genomics-based analyses of primary murine and human lung specimens as well as of patient samples to all projects, on a tissue-/cell type-specific and rare/single-cell level. This includes microarray and NGS analyses, as well as storing, bioinformatics processing and integrative modeling of acquired data from experimental, pre-clinical and clinical studies. In long term, it is envisioned to establish algorithms to systematically integrate complex datasets acquired in all projects for multi-component disease and target modeling as well as biomarker identification in the specific context of virus-induced lung injury.

 

Epigenetics Unit

To provide unrestricted access to the rapidly evolving methodology of chromatin profiling of scarce cell subsets from clinical samples, the CRU infrastucture will be further extended by an epigenetics unit supervised by M. Looso and T. Braun (P8). This unit is dedicated to cutting edge epigenetic landscape modeling of flow-sorted human cell subsets from BALF or blood samples to assess multiple layers of chromatin regulation and allow deep phenotyping of human cells in a disease-specific context. This unit will be available to all CRU-associated clinicians and, in long term, will be implemented as permanent facility associated to the Department of Medicine II, to provide epigenetic profiling of rare cells derived from patients with different entities of lung or infectious diseases, aiming at future development of more personalized treatment approaches within a precision medicine concept.

 http://www.mpi-hlr.de/forschung/servicegruppen/bioinformatik.html

Principal Investigators

Torsten Hain

PD Dr. rer. nat. Torsten Hain

Justus Liebig University Giessen
Institute of Medical Microbiology 
Schubertstraße 81; 35392 Giessen

+49-641-99-39860
Alexander Goesmann

Prof. Dr. Alexander Goesmann

Systems Biology
Heinrich-Buff-Ring 58; 35392 Giessen

+49 641 99-35800
Jochen Wilhelm

Dr. rer. nat. Jochen Wilhelm

Justus Liebig University Giessen
Department of Medicine II
Gaffkystr. 11; 35392 Giessen

+49-641-99-42545
Jürgen Lohmeyer

Prof. Dr. med. Jürgen Lohmeyer

Vice speaker

Justus Liebig University Giessen
Department of Internal Medicine II
Klinikstr. 33; 35392 Giessen

+49-641-985-57060

Project group

  • Mario Looso

    Dr. Mario Looso

    +49-6032-705-1763
  • Burkhard Linke

    Dr. Burkhard Linke

    Postdoc

  • Monika Heiner

    Dr. Monika Heiner

    Postdoc

  • Balachandar Selvakumar

    Dr. Balachandar Selvakumar

    Postdoc

  • Jan Philipp Mengel

    Jan Philipp Mengel

    PhD student

  • Julia Bespalowa

    Julia Bespalowa

    Technician

    +49-641-985-42712
  • Susanna Ziegler

    Susanna Ziegler

    Technician