KFO309 - The clinical research unit Virus Induced Lung injury

Principal Investigators

Torsten Hain

PD Dr. rer. nat. Torsten Hain

Justus Liebig University Giessen
Institute of Medical Microbiology 
Schubertstraße 81; 35392 Giessen

+49-641-99-39860
Alexander Goesmann

Prof. Dr. Alexander Goesmann

Systems Biology
Heinrich-Buff-Ring 58; 35392 Giessen

+49 641 99-35800
Jochen Wilhelm

Dr. rer. nat. Jochen Wilhelm

Justus Liebig University Giessen
Department of Medicine II
Gaffkystr. 11; 35392 Giessen

+49-641-99-42545
Mario Looso

Dr. Mario Looso

Head of Bioinformatics Service Facility

Max Planck Institute for Heart and Lung Research

Ludwigstrasse 43

61231 Bad Nauheim

http://www.mpi-hlr.de/forschung/servicegruppen/bioinformatik.html

 
 
 
 
 
 
 
 
 
 
 
 
+49-6032-705-1763

Core unit “Genome signatures and integrated systems biology of pathogen-host interaction and cellular networks in the infected and injured lung”

Summary

Understanding cell-specific gene regulatory events and their impact on cellular networks in infected lungs requires an integrative CRU platform which delivers high-throughput transcriptomics, genomics and epigenetics analyses from primary lung cells/organoids/tissues including highly purified cell populations even of rare subsets, as well as advanced tools for data exploitation. The core unit (Z1) provides methods and tools for processing of murine and human lung specimens including patient samples to all CRU projects, with a focus on cell specificity and after prior processing/enrichment of rare cell populations by Auto-MACS and FACS. Furthermore, automated sample/library preparation, whole-transcriptome analyses by microarrays and next-generation sequencing (NGS) including single cell RNA sequencing (scRNA-Seq) and droplet-based approaches (Drop-Seq) for transcriptomics and epigenomics, as well as microbiome/metagenome analysis are cutting edge techniques provided by Z1. A comprehensive portfolio of bioinformatics software solutions is offered to all CRU members to process and analyze the above-mentioned data sets in a standardized and highly automated fashion.

Z1 bersicht

 

 Hompage MPI Bioinformatic

Homepage Goesmann lab

Single Cell RNAseq technique

Publications

Peptidoglycan Recognition Protein 4 Limits Bacterial Clearance and Inflammation in Lung by Control of the Gut Microbiota

Front Immunol 2019 10:2106










Principal Investigators

Torsten Hain

PD Dr. rer. nat. Torsten Hain

Justus Liebig University Giessen
Institute of Medical Microbiology 
Schubertstraße 81; 35392 Giessen

+49-641-99-39860
Alexander Goesmann

Prof. Dr. Alexander Goesmann

Systems Biology
Heinrich-Buff-Ring 58; 35392 Giessen

+49 641 99-35800
Jochen Wilhelm

Dr. rer. nat. Jochen Wilhelm

Justus Liebig University Giessen
Department of Medicine II
Gaffkystr. 11; 35392 Giessen

+49-641-99-42545
Mario Looso

Dr. Mario Looso

Head of Bioinformatics Service Facility

Max Planck Institute for Heart and Lung Research

Ludwigstrasse 43

61231 Bad Nauheim

http://www.mpi-hlr.de/forschung/servicegruppen/bioinformatik.html

 
 
 
 
 
 
 
 
 
 
 
 
+49-6032-705-1763

Project group

  • Burkhard Linke

    Dr. Burkhard Linke

    Postdoc

  • Andreas Hoek

    Andreas Hoek

    Bioinformatician

  • Monika Heiner

    Dr. Monika Heiner

    Postdoc

  • Balachandar Selvakumar

    Dr. Balachandar Selvakumar

    Postdoc

  • Jan Philipp Mengel

    Jan Philipp Mengel

    PhD student

  • Julia Bespalowa

    Julia Bespalowa

    Technician

    +49-641-985-42712
  • Susanna Ziegler

    Susanna Ziegler

    Technician